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KMID : 1161420150180010102
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Journal of Medicinal Food
2015 Volume.18 No. 1 p.102 ~ p.108
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Lipid-Soluble Ginseng Extract Inhibits Invasion and Metastasis of B16F10 Melanoma Cells
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Yun Ji-Eun
Kim Bo-Geun
Kang Jong-Soon
Park Song-Kyu
Lee Ki-Ho
Hyun Dong-Hoon
Kim Hwan-Mook
In Man-Jin
Kim Dong-Chung
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Abstract
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This study was performed to elucidate the effect of a lipid-soluble ginseng extract (LSGE) on cancer invasion and metastasis. The LSGE, even at noncytotoxic concentrations, potently inhibited invasion and migration of B16F10 mouse melanoma cells in a dose-dependent manner. In the presence of 3 μg/mL of LSGE, the invasion and migration of B16F10 cells were significantly inhibited by 98.1% and 71.4%, respectively. Furthermore, the LSGE decreased mRNA and protein levels of matrix metalloproteinase (MMP)-2 in B16F10 cells, leading to a decrease in MMP-2 activity. After B16F10 cells were intravenously injected in the tail vein of C57BL/6 mice, 1000?mg/kg/day of LSGE was orally administered for 13 days, after which lung metastasis of cancer cells was inhibited by 59.3%. These findings indicate that LSGE inhibits cancer cell invasion and migration in vitro and lung metastasis of melanoma cells in vivo by inhibiting MMP-2 expression.
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KEYWORD
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cancer invasion, lipid-soluble ginseng extract, lung metastasis, matrix metalloprotease-2
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